Phentermine Pharmacokinetics
Phentermine 37.5 mg is a sympathomimetic amine with pharmacological activity similar to amphetamines. It works as a central nervous system stimulant. After oral administration, it is rapidly absorbed from the gastrointestinal tract. The peak plasma concentration occurs within 3 to 4.4 hours. Its half-life ranges between 16 and 31 hours. Factors such as pH can influence its absorption and excretion. Urinary pH can alter the rate at which it is expelled from the body.
The metabolism of Phentermine 37.5 mg predominantly occurs in the liver. It is excreted in the urine. Minimal amounts undergo N-oxidation and deamination. While most of the compound remains unchanged, some metabolites contribute to its pharmacological activity. This process is important for determining the appropriate dosing regimen for individuals.
Areas of Use
Phentermine 37.5 mg is prescribed as a short-term adjunct in a regimen of weight reduction. It is aimed at individuals with an initial body mass index (BMI) ≥30 kg/m², or ≥27 kg/m² with comorbid conditions. It acts by stimulating the hypothalamus to release norepinephrine. This action increases heart rate and blood pressure while decreasing appetite.
Alongside caloric restriction and exercise, it helps achieve significant weight loss. Phentermine 37.5 mg is not recommended for cosmetic weight loss. Its use is confined to those with a substantial medical need due to obesity-related health risks. Proper dietary and lifestyle modifications are essential for efficacy.
Phentermine Warnings
Phentermine 37.5 mg is contraindicated in individuals with a history of cardiovascular diseases. It should not be used in cases of hyperthyroidism, glaucoma, or a history of drug abuse. The compound may exacerbate existing cardiovascular conditions due to its stimulatory effects.
Caution is advised for individuals with hypertension or diabetes. Monitoring blood pressure and glycemic levels is recommended. Concomitant use with other CNS stimulants is discouraged. Its potential for dependency and abuse warrants careful prescribing practices.
Phentermine Storage
Store Phentermine 37.5 mg in a tightly closed container at room temperature. Protect it from light and moisture. Keep it out of reach of children. Proper storage ensures the stability and potency of the medication over time.
Pharmacy guidelines recommend discarding expired or unused medication. This prevents accidental ingestion or misuse. Adherence to storage protocols maximizes the drug’s efficacy and safety.
Adverse Effects
Phentermine 37.5 mg may cause various side effects. Common reactions include insomnia, dry mouth, and constipation. Cardiovascular effects like palpitations and increased heart rate are also reported. These effects are due to its sympathomimetic nature.
Serious adverse events, though rare, include primary pulmonary hypertension and valvular heart disease. If experienced, immediate medical attention is required. The risk of serious side effects is mitigated by adhering to recommended dosages.
Phentermine For Sale Online
Phentermine 37.5 mg is available through various online platforms. Purchasing medications online requires caution. Ensure that the source is reputable and licensed. Counterfeit drugs are prevalent in the digital marketplace.
Consult with healthcare providers before purchasing. Verify the legitimacy of online pharmacies through resources such as the FDA website. This ensures the procurement of safe and effective medication.
| Parameter | Details |
|---|---|
| Absorption | Rapid |
| Peak Plasma Time | 3 to 4.4 hours |
| Half-Life | 16 to 31 hours |